US stocks opened lower on Tuesday as earnings season was set to begin, with investors cautious after the economy plodded along during the fourth quarter of 2012.
Five minutes into trade, the Dow Jones Industrial Average was down 28.68 points (0.21 per cent) at 13,355.61.
The broad-based S&P 500 fell 3.05 points (0.21 per cent) to 1458.84, while the tech-heavy Nasdaq Composite edged down 0.95 (0.03 per cent) to 3097.86.
Monsanto shares surged 3.1 per cent to $US99.05 ($A94.78) after reporting a 169 per cent rise in profit for its quarter to November 30 on strong corn seed sales in the US and Latin America.
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